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  • Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections .
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  • [ edit ] Mechanism of action .
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  • [7] [8] [9] [10] [11] [12] When used with an alpha blocker , take them at least four hours apart to avoid hypotension .
  • NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection.
  • [17] [18] [ edit ] See also .
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  • Reduction of nitro group to amino.
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